Vitamin K Dependent Clotting Factors Mnemonic

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Vitamin k dependent clotting factors mnemonic. Warfarin inhibits the cyclic interconversion of vitamin k to a. It is commonly used for prevention and treatment of vte prevention of stroke in atrial fibrillation anticoagulation for mechanical prosthetic heart valves and myocardial infarction prevention in coronary artery disease. The child grew up got 10 upon 10 marks. Without carboxylation clotting factors proteins are not activated and clotting cascade does not occur.

To remember the vitamin k dependent factors try to memorize this picture. Mnemonic for clotting factors. Summary vitamin k is a fat soluble vitamin synthesized by intestinal bacteria. Therefore vitamin k plays an important role in coagulation formation of blood clots as there are a number of such vitamin k dependent.

Warfarin 4 hydroxycoumarin inhibits the synthesis of vitamin k dependent coagulation factors including factors ii vii ix and x as well as proteins c and s. A vitamin k deficiency will predispose you to bleeding and blocking vitamin k prevents inappropriate clotting. Hemorrhage due to decreased vitamin k dependent clotting factors. Vitamin k dependent clotting factors mnemonic 1972 factors x ix vii ii also proteins c and s.

Fat soluble vitamin synthesized by intestinal bacteria. Factors 10 9 7 2 w. Clotting factors are usually inactive but once there is an injury to the wall of the blood vessel they get activated. Vitamin k is an essential cofactor in the activation of certain proteins within your body 1.

Clotting factors are therefore known as procoagulants. In year 2k 2000 factor 2 is k dependant a pregnant lady after carrying her child for 9 months caring all 7 days a week gave birth to a child. Extrinsic pathway is activated by tissue thromboplastin. Vitamin k is activated by the enzyme epoxide reductase to its reduced form which acts as a cofactor for gamma carboxylation of glutamic acid residues on blood clotting proteins.

Warfarin acts on extrinsic pathway prothrombin time used to check it. The function of clotting factors is to trigger the formation of a blood clot and stabilize it for as long as necessary. Cystic fibrosis pancreatic insufficiency crohn s malnourishment or long term antibiotic use. They are factors 2 7 9 10 the story behind the picture mnemonic.

Typically seen with fat malabsorption e g. Prothrombin time factors x ix vii ii are vitamin k dependent. F reshers p arty t. These are vitamin k dependent coagulation factors and affected most by liver disease and warfarin.

Intrinsic pathway is activated by subendothelial collagen. Normal pt is 12 16 seconds. If you know this the other one is the other one. Factors ii vii ix and x require calcium factor iv and phospholipid pl for activation.

Extrinsic pathway is affected and hence pt inr is elevated.