Vitamin K Dependent Clotting Factors Liver

It is commonly used for prevention and treatment of vte prevention of stroke in atrial fibrillation anticoagulation for mechanical prosthetic heart valves and myocardial infarction prevention in coronary artery disease.

Vitamin k dependent clotting factors liver. Vitamin k is an essential cofactor in the activation of certain proteins within your body 1. With the participation of vitamin k vitamin k dependent coagulation factors ii vii ix and x synthesize in the liver. Factors vii ix and x. We aimed to assess whether vitamin k administration increases the levels of the vitamin k dependent factor vii fvii protein c and protein s in patients with different stages of liver dysfunction.

The extent of coagulation abnormalities depends upon the degree of disturbed liver function. A vitamin k deficiency will predispose you to bleeding and blocking vitamin k prevents inappropriate clotting. Acute or chronic hepatocellular diseases may display decreases in the vitamin k dependent factors prothrombin. In the molecular structure of these coagulation factors there are different numbers of γ carboxyglutamic acid γ gla residues which locate in the n terminal of their own genes in physiological conditions these glutamate residues have γ carboxylation.

Without the activation step certain biochemical reactions cannot be completed. Warfarin 4 hydroxycoumarin inhibits the synthesis of vitamin k dependent coagulation factors including factors ii vii ix and x as well as proteins c and s.